Dr Hal Brown, Naturopathic Physician
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Journal of Prolotherapy Article on

Neural Prolotherapy


There are many new developments in the world of regenerative Orthopedic Medicine. One innovative treatment option is called Neural Prolotherapy. Traditional Prolotherapy has focused on ligament-tendon healing, and has shown to be a powerful treatment modality. With Neural Prolotherapy, however we shift our focus to the subcutaneous nerves as a source of pathology. These subcutaneous nerves in a pathologic state can lead to neurogenic inflammation and pain. We introduce and explore the use of low dose dextrose Prolotherapy in the treatment of neurogenic inflammatory pain. Neural Prolotherapy is indeed a fantastic treatment option that has the potential to further our healing profession.

Journal of Prolotherapy. 2011;3(2):639-643.


Nerves Of The Knee Nerves of the knee

Sub-cutaneous nerves of the knee:


Vancouver Neural Prolo Therapy - NPT

or Peri-neural Injection Therapy - PIT

A new approach in Regenerative Orthopedic Medicine and injury treatment

It is a very effective treatment for many injuries and ongoing joint, tendon, ligament and muscle pain.

Neural Prolotherapy was developed by the clinical observations of Dr. John Lyftogt MD in Christchurch, New Zealand.

NPT should not be confused with “German” Neural Therapy injection or with Prolotherapy. It is similar, to those therapies in that it treats the same conditions, but targets different causative factors. It is the treatment of neurogenic inflammation, that is it is treating nerves as a cause of joint and muscle pain. 

How Does It Work?

Neural prolotherapy does not target tendons, ligaments or joints, but does treat nerves associated with the pain areas. Seeing dramatic results, many ask how does it work, causing such significant and often immediate decline in pain levels after even a few treatments.

Dr. Lyftgot's working hypothesis is that glucose injected into affected points, assists in the repair of connective tissue in the subcutaneous nerves (under the skin) . These skin nerves are known to be responsible for painful conditions generally identified as ‘neuralgias’ or ‘peripheral neuropathic pain’.

There is compelling scientific evidence that these small nerves are responsible for inflammation of the connective tissue and of surrounding areas. Inflammation of nerves is known to be related to osteoarthritis.

This ‘neurogenic inflammation’ is different than common inflammation in that it does not respond to anti-inflammatory medication or cortisone shots. It is clear from clinical observations on more than three thousand patients and large case series that neural Prolotherapy effectively reverses ‘neurogenic inflammation’ and resolves neuralgia and joint pains.

Treatment Protocol

Treatment typically involves 4-6 sessions of micro-injections just under the skin with a very small needle. (Some persons occasionally require more than 6-8 treatments). One treatment may take 10-20 minutes. Although 4-6 treatments are usually required , patients will experience significant relief after one treatment. Usually this relief only lasts a few hours or days, but it does indicate that neural-prolotherapy will be effective after a course of treatment. After the treatment patients may have some brief tenderness at the injection site or some bruising may develop. Physical activity is not restricted post-injection, and may return to their usual activities right away. Most patients tolerate the minimal discomfort associated with the injections without a problem. The occasional patient however who is needle phobic or quite pain sensitive may not be a good candidate.

Naturopathic Use of Neural Prolotherapy

In my practice NPT, prolotherapy, PRP and neural therapy are often used in conjunction with each other to resolve chronic pain conditions. Other treatments such as PRP, MSC, spinal and joint adjustments, acupuncture, trigger point injections and biological and nutritional therapies are also used as required.  Each patient is unique, the best treatment should be used at each stage of a healing process.