Dr Hal Brown, Naturopathic Physician
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Prolotherapy/Regenerative Injection Therapy Pages on this Site:

What is Prolotherapy?

Prolotherapy Benefits

Naturopathic Integrated Approach to Prolotherapy

Prolotherapy, PRP articles

After Treatment Guidelines

Patient Testimonials for Prolotherapy

Mayo Clinic, US Surgeon General
and NIH endorse Prolotherapy:

In 2005, the Mayo Clinic endorsed prolotherapy, saying it may be helpful when ligament or tendon pain fails to respond to prescribed physical therapy. The procedure is endorsed by former U.S.Surgeon General C. Everett Koop, and is part of clinical trial being conducted by the National Center for Complementary and Alternative Medicine (National Institute of Health.)

Research In PRP Prolotherapy

Platelet Rich Plasma (PRP) Matrix Graft by David Crane, MD and Peter A.M. Everts PhD


Summary: "The improvements in pain levels and functional ability after injection is supportive of tendon and ligaments being a major source of symptomatology in fibromyalgia..."

Knee Injuries:

Long Term Effects Of Dextrose Prolotherapy For Anterior Cruciate Ligament Laxity
University of Kansas Medical Center, Alternative Therapies, May/June 2003, Vol. 9 No. 3

CONCLUSION: In patients with symptomatic anterior cruciate ligament laxity, intermittent dextrose injection resulted in clinically and statistically significant improvement in ACL laxity, pain, swelling, and knee range of motion.

Knee Arthritis:

X-rays of regeneration of a knee from prolotherapy

Journal of Practical Pain Management  July, Aug., 2007 :Prolotherapy for Knee Pain

Knee Arthritis Study Using Dextrose Prolotherapy
University of Kansas Medical Center, Alternative Therapies, March 2000, Vol. 6, No 2
Conclusions: Prolotherapy injection with 10% dextrose resulted in clinically and statistically significant improvements in knee osteoarthritis. Preliminary blinded radiographic readings (1-year films, with 3-year total follow-up period planned) demonstrated improvement in several measures of osteoarthritis severity. ACL laxity, when present in these osteoarthritic patients, improved,

Chart from the study

pain swelling buckling

Prolotherapy Lectures by

Dr. Marc Darrow

Part 1

Part 2

Part 3

Part 4

Part 5










Prolotherapy Articles

Running Injuries: Prolotherapy and PRP Treatment; Dr. Hal Brown NDNR journal

Injections to Kick-Start Tissue Repair
New York Times

Shots Bring Headache Relief

Yoga Journal: Sugar Fix For Torn Ligaments
Dr. Allen Thomashefsky

Sweet Relief
by K. Dean Reeves, MD

A Brand New Way To Get Rid Of Pain (Woman's World Magazine)
by Ross Hauser, M.D.

Prolotherapy for Musculo-skeletal Pain
A primer for pain management physicians on the mechanisms of actions and indications for use. Journal of Practical Pain Management Jan/Feb., 2007

Prolotherapy for Low Back Pain
Journal of Practical Pain Management May, 2007

Prolotherapy for Knee Pain
Journal of Practical Pain Management   July, Aug., 2007

Prolotherapy: Dextrose Prolotherapy for Unresolved Neck Pain
In this study, 97 out of 98 patients with chronic neck pain showed substantial improvement in numerous outcome measures. The improvements in these patients continued through follow up—18 months after conclusion of prolotherapy treatments—and demonstrates the efficacy of this treatment modality.

Sports Groin Injuries:

Efficacy of Dextrose Prolotherapy in Elite Male Kicking-Sport Athletes With Chronic Groin Pain   Archives of Physical Medicine and Rehabilitation 2005; 86: 697-702
Conclusions: "Dextrose Prolotherapy showed marked efficacy for chronic groin pain in this group of elite rugby and soccer athletes."

Low Back Pain:

Retrospective Case Series on Patients with Chronic Spinal Pain Treated with Dextrose Prolotherapy
Results: 91% of patients reported reduction in level of pain; 84.8% of patients reported improvement in activities of daily living, and 84.3% reported an improvement in ability to work.
Conclusions: “Dextrose prolotherapy appears to be a safe and effective method for treating chronic spinal pain..."

Chronic Pain:

A Systematic Review of Prolotherapy for Chronic Musculo-skeletal Pain
Clinical Journal of Sports Medicine; 15(5):E376, September 2005
Conclusions: “Positive results compared with controls have been reported in nonrandomized and randomized controlled trials."

Chronic pain: What colour are the emperor’s new clothes?
Canadian Journal of Anesthesia, 52:R4 (2005)
Recommendation: "Prolotherapy is most appropriate and effective in carefully selected and monitored patients who are participating in an appropriate program of exercise and/or manipulation / mobilization."

PRP (Platelet Rich Plasma) Regenerative Injection Therapy

Globe and Mail: Injured? Heal yourself with your own blood.

PRP Prolotherapy used successfully for professional athletes

Takashi Saito, Dodger's Pitcher regains career after PRP treatment to his elbow

PRP keeps Hines Ward and Troy Polamalu of the Pittsburgh Steelers  in the game

What is PRP; Platelet Rich Plasma Prolotherapy?

PRP used by figure skater Patrick Chan, Canadian Olympic Team Doctor, B.C. Lions

Research in PRP:  Platelet Rich Plasma (PRP) Matrix Graft by David Crane, MD and Peter A.M. Everts PhD


More Links: Prolotherapy can help with...